Basic Information
ID: ALA1131823
Journal: Bioorg Med Chem Lett
Title: Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK).
Authors: Aicher TD, Damon RE, Koletar J, Vinluan CC, Brand LJ, Gao J, Shetty SS, Kaplan EL, Mann WR.
Abstract: Several oximes of triterpenes with a 17-beta hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse after a single oral dose of 100 micromol/kg. However, the mechanism of the blood glucose lowering effect is likely unrelated to PDK inhibition.
CiteXplore: 10465550
DOI: 10.1016/s0960-894x(99)00380-7
Patent ID: ┄
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