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ID: ALA1131836

Journal: Bioorg Med Chem Lett

Title: Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.

Authors: Carlier PR, Du DM, Han Y, Liu J, Pang YP.

Abstract: Hybrid acetylcholinesterase inhibitors composed of a key fragment of huperzine A and an intact tacrine unit were prepared. The syntheses are quite direct, proceeding in a maximum of 4 linear steps from commercially available starting materials. The optimum hybrid inhibitor (+/-)-9g is 13-fold more potent than (-)-huperzine A, and 25-fold more potent than tacrine.

CiteXplore: 10476864

DOI: 10.1016/s0960-894x(99)00396-0