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ID: ALA1131841
Journal: Bioorg Med Chem Lett
Title: Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain.
Authors: Peet NP, Kim HO, Marquart AL, Angelastro MR, Nieduzak TR, White JN, Friedrich D, Flynn GA, Webster ME, Vaz RJ, Linnik MD, Koehl JR, Mehdi S, Bey P, Emary B, Hwang KK.
Abstract: The synthesis of [1-[(5-hydroxy-4-(phenylmethyl)-3-oxazolidinyl)carbonyl]-2-ethylpropy lcarbamic acid phenylmethyl ester (2; MDL 104,903), a potent inhibitor of calpain, is described. Synthesis of related compounds, which offer insights into the mechanism of action for 2, are also described, as is an O-acetyl prodrug derivative of 2.
CiteXplore: 10476870