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ID: ALA1131848
Journal: Bioorg Med Chem Lett
Title: 8-aminoquinolines as anticoccidials - Part III.
Authors: Armer RE, Barlow JS, Chopra N, Dutton CJ, Greenway DH, Greenwood SD, Lad N, Shaw J, Thompson AP, Thong KW, Tommasini I.
Abstract: Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated. Novel analogues of equal or improved efficacy in vitro and in vivo to pentaquine were discovered.
CiteXplore: 10476881