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ID: ALA1131855
Journal: Bioorg Med Chem Lett
Title: Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70.
Authors: Vu CB, Corpuz EG, Pradeepan SG, Violette S, Bartlett C, Sawyer TK.
Abstract: The synthesis of a series of 1,2,4-oxadiazole analogs is discussed along with their ZAP-70 SH2 inhibitory activity. The tyrosine moiety in the original series has been replaced with nonpeptidic functional groups without a substantial loss of binding affinity.
CiteXplore: 10571165