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ID: ALA1131861
Journal: Bioorg Med Chem Lett
Title: Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives.
Authors: Ohyama M, Tanaka T, Ito T, Iinuma M, Bastow KF, Lee KH.
Abstract: Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The acetate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activity with ED50 values of 0.6, 0.7 and 2.0 microg/mL against KB, 1A9 and MCF-7 cells, respectively. Hopeaphenol (10) and pallidol hexaacetate (13) also showed significant cytotoxicity against KB cells with ED50 values of 1.2 and 1.6 microg/mL, respectively.
CiteXplore: 10571175