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ID: ALA1131868
Journal: Bioorg Med Chem Lett
Title: Alpha-trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines.
Authors: Kawase M, Sakagami H, Kusama K, Motohashi N, Saito S.
Abstract: Cytotoxic activity of newly synthesized trifluoromethyl ketones and related compounds was studied using two human oral tumor cell lines (HSG and HSC-2). Among them, alpha-trifluoromethylacyloins (1 and 2) were found to induce apoptotic cell death, as judged by the terminal deoxynucleotidyl transferase (TdT) dUTP nick end-labeling (TUNEL) method which detects DNA nick or fragments. Furthermore, the cytoplasm of 1 or 2 treated HSG cells was stained by M30 monoclonal antibody, which detects the product resulting from the cleavage of cytokeratin 18 by activated caspase.
CiteXplore: 10560735