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ID: ALA1131874
Journal: Bioorg Med Chem Lett
Title: Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.
Authors: De Jonghe S, Van Overmeire I, Gunst J, De Bruyn A, Hendrix C, Van Calenbergh S, Busson R, De Keukeleire D, Philippé J, Herdewijn P.
Abstract: Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-serine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cell lines and compared with their hydroxylated counterparts.
CiteXplore: 10560744