Document Report Card
Basic Information
ID: ALA1131880
Journal: Bioorg Med Chem Lett
Title: Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues.
Authors: Jew S, Kim HJ, Kim MG, Roh EY, Hong CI, Kim JK, Lee JH, Lee H, Park H.
Abstract: A series of C(7)-N-alkylaminoethyl-C(10), C(11)-methylenedioxy- and ethylenedioxy-camptothecin (3a-g, 4a-b) were prepared. Their syntheses and in vitro cytotoxicity were reported. Among 15 derivatives, 3a and 3b showed more potent cytotoxicity than Camptothecin, especially in CAOV-3 cell line.
CiteXplore: 10576688