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ID: ALA1131884
Journal: Bioorg Med Chem Lett
Title: Dicationic 2-fluorenonylcarbapenems: potent anti-MRS agents with improved solubility and pharmacokinetic properties.
Authors: Greenlee ML, Laub JB, Rouen GP, DiNinno F, Hammond ML, Huber JL, Sundelof JG, Hammond GG.
Abstract: The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-beta-methyl substituent was found to improve pharmacokinetics.
CiteXplore: 10576693