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ID: ALA1131890
Journal: Bioorg Med Chem Lett
Title: Syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors.
Authors: Ono S, Kuwahara S, Takeuchi M, Sakashita H, Naito Y, Kondo T.
Abstract: We report the syntheses and evaluation of amidinobenzofuran derivatives as tryptase inhibitors. Among the compounds we evaluated, 1,5-Bis[4-(5-amidinobenzofuran-2-ylcarbonyl)piperazinylca rbonylmethoxy]cyclooctane 26 (AY0068) was found to be a selective and potent non-peptide inhibitor. 26 was effective in PCA reaction in rats without showing antihistaminic activity.
CiteXplore: 10612586