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ID: ALA1131892
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings.
Authors: Ohkubo M, Nishimura T, Honma T, Nishimura I, Ito S, Yoshinari T, Suda HA, Morishima H, Nishimura S.
Abstract: In the course of a study of 6-N-amino-substituted analogues of NB-506 (1), a more potent anticancer drug, J-109,404 (2), in which the formyl group of NB-506 was replaced with a 1,3-dihydroxypropane group, was reported. A study of further modification in the positions of two hydroxyl groups at the indole rings of 2 resulted in the discovery of a 2,10-dihydroxy analogue, J-107,088 (3), which is a promising anticancer agent with a broader therapeutic window than J-109,404.
CiteXplore: 10612590