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ID: ALA1131893
Journal: Bioorg Med Chem Lett
Title: Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.
Authors: Ishida J, Wang HK, Bastow KF, Hu CQ, Lee KH.
Abstract: Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. Alpha-(4-nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 microg/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).
CiteXplore: 10612592