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ID: ALA1131898
Journal: Bioorg Med Chem Lett
Title: 4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: potent and selective inhibitors of ZAP 70.
Authors: Moffat D, Davis P, Hutchings M, Davis J, Berg D, Batchelor M, Johnson J, O'Connell J, Martin R, Crabbe T, Delgado J, Perry M.
Abstract: Activation of the tyrosine kinase ZAP 70 has been shown to be crucial to the transduction of the T-cell receptor signalling pathway, which leads ultimately to proliferation, cytokine gene expression and T-cell effector functions. A series of 2-phenylaminopyrimidines have been identified as potent and selective inhibitors of ZAP 70.
CiteXplore: 10612598