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ID: ALA1131901
Journal: Bioorg Med Chem Lett
Title: Synthesis and opiate receptor binding properties of 17-methyl-6,7-dehydro-3,14-dihydroxy-4,5alpha-epoxy-6,7:4',5'-pyrimidin omorphinans.
Authors: Xu W, Huang LF, Bauer L, Bhargava HN, Dunn WJ.
Abstract: A class of opioid receptor active derivatives of oxymorphone has been synthesized using a common enaminone intermediate. The derivatives have heterocyclic groups fused to the 6,7-positions of the morphinan system and all were synthesized in high yield. A pyrazolo derivative is an agonist for the mu and delta receptors and an antagonist for the kappa receptor.
CiteXplore: 10612602