Basic Information
ID: ALA1131902
Journal: Bioorg Med Chem Lett
Title: Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146.
Authors: Norman BH, Dantzig AH, Kroin JS, Law KL, Tabas LB, Shepard RL, Palkowitz AD, Hauser KL, Winter MA, Sluka JP, Starling JJ.
Abstract: The benzothiophene LY329146 reverses the drug resistance phenotype in multidrug resistance protein (MRP1)-overexpressing cells when dosed in combination with MRP1-associated oncolytics doxorubicin and vincristine. Additionally, LY329146 inhibited MRP1-mediated uptake of the MRP1 substrate LTC4 into membrane vesicles prepared from MRP1-overexpressing cells.
CiteXplore: 10612603
DOI: 10.1016/s0960-894x(99)00610-1
Patent ID: ┄
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