Document Report Card
Basic Information
ID: ALA1131909
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological activities of position one and three transposed analogs of the opioid peptide YKFA.
Authors: Burden JE, Davis P, Porreca F, Spatola AF.
Abstract: Tyr-c[D-Lys-Phe-Ala], YKFA, is a potent opioid peptide analog with subnanomolar IC50s toward mu and delta receptors. Transposing Phe and Tyr, a modification found to promote mu antagonist activity in opioid/somatostatin hybrids, gave surprisingly high mu agonist activities for several related analogs, considering the lack of a 1-position hydroxyl function.
CiteXplore: 10617088