Document Report Card
Basic Information
ID: ALA1131912
Journal: Bioorg Med Chem Lett
Title: Synthesis of potent and selective inhibitors of human plasma kallikrein.
Authors: Garrett GS, McPhail SJ, Tornheim K, Correa PE, McIver JM.
Abstract: The synthesis and in vitro enzyme inhibition profile of a series of novel trifluoromethylketone (TFMK) inhibitors of human plasma kallikrein (PK) are described. We have developed an efficient method for the construction of peptide TFMKs that provides the final product devoid of compromised stereochemical integrity. Many of these compounds are potent inhibitors of PK and exhibit reduced inhibition of tissue kallikrein (TK) and plasmin (HP).
CiteXplore: 10091673