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ID: ALA1131923
Journal: Bioorg Med Chem Lett
Title: Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases.
Authors: Yu XY, Hill JM, Yu G, Wang W, Kluge AF, Wendler P, Gallant P.
Abstract: A series of novel aminoacyl adenylate mimics has been prepared and evaluated for their inhibitory activity against aminoacyl-tRNA synthetases. Several of these thiazole derivatives displayed potent and selective enzyme activity against both Gram-positive and Gram-negative bacteria.
CiteXplore: 10091687