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ID: ALA1131924

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological evaluation of 1alpha,24-dihydroxy-25-nitrovitamin D3.

Authors: Oshida J, Okamoto M, Ishizuka S, Azuma S.

Abstract: 1Alpha,24(R)Dihydroxy-25-nitrovitamin D3 1 and 1alpha,24(S)-dihydroxy-25-nitrovitamin D3 2 were synthesized using the palladium-catalyzed alkylative enyne cyclization reaction. Their biological properties were studied based on VDR binding affinity and HL-60 cell differentiation activity.

CiteXplore: 10091688

DOI: 10.1016/s0960-894x(99)00013-x