Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives.

ID: ALA1131926

Journal: Bioorg Med Chem Lett

Title: Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives.

Authors: Shinozaki K, Sato H, Iwakuma T, Sato R, Kurimoto T, Yoshida K.

Abstract: A new series of indane derivatives were prepared and evaluated for their thromboxane A2 (TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA2 antagonist in oral administration.

CiteXplore: 10091692

DOI: 10.1016/s0960-894x(99)00014-1

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