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ID: ALA1131950

Journal: Bioorg Med Chem Lett

Title: Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.

Authors: Roe M, Folkes A, Ashworth P, Brumwell J, Chima L, Hunjan S, Pretswell I, Dangerfield W, Ryder H, Charlton P.

Abstract: We have synthesised and evaluated a series of anthranilamide based modulators of P-glycoprotein. These studies have identified XR9576(2), a potent inhibitor of P-glycoprotein in vitro and in vivo. The general synthesis and the SAR of these compounds are described.

CiteXplore: 10098671

DOI: 10.1016/s0960-894x(99)00030-x