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ID: ALA1131953

Journal: Bioorg Med Chem Lett

Title: Synthesis of a tetrasubstituted bicyclo [2.2.2] octane as a potential inhibitor of influenza virus sialidase.

Authors: Smith PW, Trivedi N, Howes PD, Sollis SL, Rahim G, Bethell RC, Lynn S.

Abstract: A novel synthesis of the bicyclo [2.2.2] octane ring system has been achieved utilising a tandem Henry cyclisation as the key stage. This chemistry has been employed in the synthesis of a potential inhibitor of influenza virus sialidase.

CiteXplore: 10098674

DOI: 10.1016/s0960-894x(99)00033-5