Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors.
Basic Information
ID: ALA1131954
Journal: Bioorg Med Chem Lett
Title: Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors.
Authors: Schuster M.
Abstract: Methyl- and hydroxymethyl derivatives of the highly potent glycosidase inhibitor isofagomine are accessible via aldolase-catalyzed C-C bond formation and competitively inhibit beta-glucosidase at low micromolar concentrations.
CiteXplore: 10098675
DOI: 10.1016/s0960-894x(99)00042-6
Patent ID: ┄
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