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ID: ALA1131963
Journal: Bioorg Med Chem Lett
Title: Novel benzo-fused lactam scaffolds as factor Xa inhibitors.
Authors: Tamura SY, Goldman EA, Bergum PW, Semple JE.
Abstract: Rigid benzolactam P3-P2 dipeptide mimics were designed and prepared as potential inhibitors of blood coagulation factor Xa. Methoxy substitution of the tetrahydrobenzazepinone scaffold led to potent and selective inhibitors. The synthesis and biological activities of these derivatives are reported herein.
CiteXplore: 10498211