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ID: ALA1131967

Journal: Bioorg Med Chem Lett

Title: BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II.

Authors: Lavergne O, Harnett J, Rolland A, Lanco C, Lesueur-Ginot L, Demarquay D, Huchet M, Coulomb H, Bigg DC.

Abstract: BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.

CiteXplore: 10498216

DOI: 10.1016/s0960-894x(99)00428-x