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ID: ALA1131981
Journal: Bioorg Med Chem Lett
Title: Heterocyclic analogues of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor.
Authors: Avenell KY, Boyfield I, Hadley MS, Johnson CN, Nash DJ, Riley GJ, Stemp G.
Abstract: A novel series of 5,6,7,8-tetrahydroquinazolines, 4,5,6,7-tetrahydroindazoles and 4,5,6,7-tetrahydrobenzothiazoles has been prepared, having high affinity and selectivity for the dopamine D3 receptor. The 4-methoxy-5,6,7,8-tetrahydroquinazoline 6i and 2-amino-4,5,6,7-tetrahydrobenzothiazole 8 proved to be agonists with among the highest D3 receptor affinities and selectivities reported to date.
CiteXplore: 10509922