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ID: ALA1131986
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationships of biphenyl tetrazoles as metallo-beta-lactamase inhibitors.
Authors: Toney JH, Cleary KA, Hammond GG, Yuan X, May WJ, Hutchins SM, Ashton WT, Vanderwall DE.
Abstract: Resistance to carbapenem antibiotics in gram-negative bacteria is due, in part, to expression of a wide spectrum metallo-beta-lactamase, which renders the drug inactive. Biphenyl tetrazoles containing 3-n-butyl-1-phenylpyrazole-5-carboxylates or the corresponding 5-ethyl esters were found to inhibit metallo-beta-lactamases as well as renal dehydropeptidase I to a lesser extent.
CiteXplore: 10509927