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ID: ALA1131987
Journal: Bioorg Med Chem Lett
Title: Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.
Authors: Lin NH, Abreo MA, Gunn DE, Lebold SA, Lee EL, Wasicak JT, Hettinger AM, Daanen JF, Garvey DS, Campbell JE, Sullivan JP, Williams M, Arneric SP.
Abstract: Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited Ki values ranging from 0.15 to > 10,000 nM when tested in vitro for cholinergic channel receptor binding activity (displacement of [3H](-) cytisine from whole rat brain synaptic membranes).
CiteXplore: 10509928