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ID: ALA1131991
Journal: Bioorg Med Chem Lett
Title: Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity.
Authors: Chambers RJ, Marfat A, Antognoli GW, Cheng JB, Damon DB, Kuperman AV, Liston TC, Mebus C, Pillar JS, Shirley JT, Watson JW.
Abstract: CP-199,330 (3) and CP-199,331 (4) are cysLT1 receptor antagonists that are equipotent to marketed cysLT1 receptor antagonists zafirlukast and pranlukast, show good pharmacokinetics in rats and monkeys, and are devoid of liver toxicity in monkeys as seen in CP-85,958 (1).
CiteXplore: 10509933