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ID: ALA1132017
Journal: Bioorg Med Chem Lett
Title: In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones.
Authors: Kawase M, Harada H, Saito S, Cui J, Tani S.
Abstract: Heteroaromatic trifluoromethyl ketones (TFMK's) showed strong inhibitory activity against Helicobacter pylori. The MIC50 observed for 2-trifluoroacetonylbenzoxazole (1) is 20-fold more active than metronidazole and is only twice as high as that of clarithromycin. The inhibitory mode of TFMK's on Hp growth was not related to inhibition of urease.
CiteXplore: 10021926