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ID: ALA1132024
Journal: Bioorg Med Chem Lett
Title: N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists.
Authors: Auberson YP, Acklin P, Bischoff S, Moretti R, Ofner S, Schmutz M, Veenstra SJ.
Abstract: N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine-binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsant effects in the electroshock-induced convulsion assay in mice.
CiteXplore: 10021939