Document Report Card
Basic Information
ID: ALA1132031
Journal: Bioorg Med Chem Lett
Title: 4-Oxospiro[benzopyran-2,4'-piperidines] as selective alpha 1a-adrenergic receptor antagonists.
Authors: Nerenberg JB, Erb JM, Bergman JM, O'Malley S, Chang RS, Scott AL, Broten TP, Bock MG.
Abstract: The 4-oxospiro[benzopyran-2,4'-piperidine] ring system is contained within potent class III antiarrhythmic agents. We highlight how these agents can be chemically transformed into a new class of potent (< 1 nM) and selective (> 25-fold) alpha 1a-receptor subtype adrenergic antagonists.
CiteXplore: 10021947