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ID: ALA1132034
Journal: Bioorg Med Chem Lett
Title: 6-oxa isosteres of anacardic acids as potent inhibitors of bacterial histidine protein kinase (HPK)-mediated two-component regulatory systems.
Authors: Kanojia RM, Murray W, Bernstein J, Fernandez J, Foleno BD, Krause H, Lawrence L, Webb G, Barrett JF.
Abstract: A series of 6-oxa isosteres of anacardic acids (6-higher alkyl/alkenyl-2-hydroxybenzoic acids) was synthesised and several members were discovered to be among the most potent inhibitors (IC50 values < or = 5 microM) of the bacterial two-component regulatory systems, KinA/SpoOF and NRII/NRI, reported to date. The Gram-positive antibacterial activity in selected strains is also presented.
CiteXplore: 10571153