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ID: ALA1132041
Journal: Bioorg Med Chem Lett
Title: Inhibition of human telomerase by PNA-cationic peptide conjugates.
Authors: Harrison JG, Frier C, Laurant R, Dennis R, Raney KD, Balasubramanian S.
Abstract: The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.
CiteXplore: 10340613