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ID: ALA1132059
Journal: Bioorg Med Chem Lett
Title: Antitumor agents 187: synthesis and cytotoxicity of substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-one and related compounds.
Authors: Yang ZY, Xia Y, Xia P, Tachibana Y, Bastow KF, Lee KH.
Abstract: Several substituted 8,8-dimethyl-2H,8H-pyrano[6,5-h]quinoline-2-ones and related compounds were synthesized and evaluated for their in vitro cytotoxicity against a panel of human tumor cell lines. The most active compound (3) showed significant cytotoxic activity with GI50 values in the micromolar range.
CiteXplore: 10201834