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ID: ALA1132068
Journal: Bioorg Med Chem Lett
Title: A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor.
Authors: Kimura T, Matsumoto H, Matsuda T, Hamawaki T, Akaji K, Kiso Y.
Abstract: Conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor were synthesized, which expressed excellent antiviral activity compared with that of the individual components. The remarkable antiviral activity of the conjugated compounds may be due to their penetration into the cell and later splitting into two different classes of anti-HIV agents.
CiteXplore: 10206539