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ID: ALA1132073
Journal: Bioorg Med Chem Lett
Title: Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities.
Authors: Kitano K, Machida H, Miura S, Ohrui H.
Abstract: Two novel 4'-C-methylnucleosides, 4'-methylBVDU 9 and 4'-methylBVaraU 10, were synthesized. The former was derived from 3',5'-di-O-acetyl-2'-deoxy-4'-C-methyluridine 12, and the latter was produced via glycosylation between 4-C-methyl-D-ribose derivative 11 and a silylated bromovinyl uracil. 4'-MethylBVDU 9 exhibited particularly potent anti-varicella-zoster virus (VZV) activity in vitro.
CiteXplore: 10206544