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ID: ALA1132088
Journal: Bioorg Med Chem Lett
Title: Three-dimensional structure-function relationship of vitamin D: side chain location and various activities.
Authors: Yamamoto K, Ooizumi H, Umesono K, Verstuyf A, Bouillon R, DeLuca HF, Shinki T, Suda T, Yamada S.
Abstract: The various biological activities of side-chain mobility restricted analogs, four diastereomers at C(20) and C(22) of 22-methyl-1alpha,25-dihydroxyvitamin D3, were evaluated. The relationship between structure and the various activities of the analogs was discussed in terms of the active space region concept that we previously suggested.
CiteXplore: 10230636