Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists.

ID: ALA1132092

Journal: Bioorg Med Chem Lett

Title: Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists.

Authors: Ryder TR, Hu LY, Rafferty MF, Lotarski SM, Rock DM, Stoehr SJ, Taylor CP, Weber ML, Miljanich GP, Millerman E, Szoke BG.

Abstract: Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers.

CiteXplore: 10476886

DOI: 10.1016/s0960-894x(99)00405-9

Patent ID: ┄