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ID: ALA1132124
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands.
Authors: Cordi A, Lacoste JM, Audinot V, Millan M.
Abstract: The in vitro activities of 3-hydroxy-imidazolidin-4-one derivatives demonstrated very restricted structure-activity relationships at the strychnine-insensitive glycine site of the NMDA receptor. The most active compound (3a) was completely unsubstituted and exhibited affinity and efficacy similar to that of D-cycloserine, the prototypical partial agonist at this site.
CiteXplore: 10360746