Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors.

ID: ALA1132126

Journal: Bioorg Med Chem Lett

Title: Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors.

Authors: Covassin L, Desjardins M, Charest-Gaudreault R, Audette M, Bonneau MJ, Poulin R.

Abstract: A series of novel spermidine and sym-norspermidine dimers was synthesized by crosslinking the polyamine backbones via alkylation of their secondary amino groups to butyl, trans-2-butenyl, 2-butynyl or p-xylyl bridges. The resulting hexamines behaved as high-affinity antagonists of polyamine uptake, with a relative potency that was dependent on the geometry of the linker structure.

CiteXplore: 10397506

DOI: 10.1016/s0960-894x(99)00262-0

Patent ID: ┄