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ID: ALA1132139
Journal: Bioorg Med Chem Lett
Title: 2-Naphthylcarbapenems: broad spectrum antibiotics with enhanced potency against MRSA.
Authors: Greenlee ML, DiNinno F, Herrmann JJ, Jaworsky C, Muthard DA, Salzmann TN.
Abstract: A regioisomeric set of 2-naphthylcarbapenems featuring cationic substituents was synthesized. Optimal placement of the cationic group was found to markedly improve activity against methicillin-resistant staphylococci while maintaining a good spectrum of gram-negative activity.
CiteXplore: 10522713