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ID: ALA1132163

Journal: Bioorg Med Chem Lett

Title: 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.

Authors: Imbach P, Capraro HG, Furet P, Mett H, Meyer T, Zimmermann J.

Abstract: Novel 2,6,9-substituted purine derivatives represent a class of potent and selective inhibitors of CDK1/cyclinB. The synthesis, SAR and biological profile of selected compounds are described.

CiteXplore: 9990463

DOI: 10.1016/s0960-894x(98)00691-x