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ID: ALA1132267
Journal: Bioorg Med Chem Lett
Title: Synthesis and antibacterial properties of beta-diketone acrylate bioisosteres of pseudomonic acid A.
Authors: Bennett I, Broom NJ, Cassels R, Elder JS, Masson ND, O'Hanlon PJ.
Abstract: A series of beta-diketone acrylate bioisosteres 4 of pseudomonic acid A 1 have been synthesized and evaluated for their ability to inhibit bacterial isoleucyl-tRNA synthetase and act as antibacterial agents. A number of analogues have excellent antibacterial activity. Selected examples were shown to afford good blood levels and to be effective in a murine infection model.
CiteXplore: 10406653