Basic Information
ID: ALA1132268
Journal: Bioorg Med Chem Lett
Title: Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.
Authors: Ciccarone TM, MacTough SC, Williams TM, Dinsmore CJ, O'Neill TJ, Shah D, Culberson JC, Koblan KS, Kohl NE, Gibbs JB, Oliff AI, Graham SL, Hartman GD.
Abstract: The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Substitutions on an imidazolylmethyl-AMBA-methionine template gave a highly potent and cell-active inhibitor.
CiteXplore: 10450968
DOI: 10.1016/s0960-894x(99)00323-6
Patent ID: ┄
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