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ID: ALA1132513

Journal: Bioorg Med Chem Lett

Title: Manipulation of the C(22)-C(27) region of rapamycin: stability issues and biological implications.

Authors: Nelson FC, Stachel SJ, Eng CP, Sehgal SN.

Abstract: A novel series of rapamycin derivatives with modifications in the C(22)-C(27) region has been prepared. These compounds are evaluated for their ability to prevent ring fragmentation while still retaining immunosuppressive capabilities.

CiteXplore: 10021948

DOI: 10.1016/s0960-894x(98)00735-5