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ID: ALA1132513
Journal: Bioorg Med Chem Lett
Title: Manipulation of the C(22)-C(27) region of rapamycin: stability issues and biological implications.
Authors: Nelson FC, Stachel SJ, Eng CP, Sehgal SN.
Abstract: A novel series of rapamycin derivatives with modifications in the C(22)-C(27) region has been prepared. These compounds are evaluated for their ability to prevent ring fragmentation while still retaining immunosuppressive capabilities.
CiteXplore: 10021948