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ID: ALA1132530
Journal: Bioorg Med Chem Lett
Title: Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.
Authors: Hanessian S, Bouzbouz S, Boudon A, Tucker GC, Peyroulan D.
Abstract: A series of acyclic hydroxamic acids harboring strategically placed alpha-arylsulfonamido and thioether groups was synthesized and found to be potent inhibitors of various MMPs. An unprecedented cleavage of t-butyl hydroxamates to hydroxamic acids was found.
CiteXplore: 10397503