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ID: ALA1132532
Journal: Bioorg Med Chem Lett
Title: Correlation of anti-HIV activity with structure: use of electrostatic potential and conformational analysis.
Authors: Mickle T, Nair V.
Abstract: Electrostatic potential distribution, 3-D electron density shapes, and conformational analysis were used to correlate anti-HIV activity or inactivity of AZT, (-) carbovir, oxetanocin A, and 16 isomeric dideoxynucleosides of different families. The structure-activity profile discovered is significant and is expected to contribute to the development of a much needed predictive QSAR analysis in this area.
CiteXplore: 10450963