Document Report Card

ID: ALA1132573

Journal: J Med Chem

Title: Novel antitumor 2-cyanoaziridine-1-carboxamides.

Authors: Iyengar BS, Dorr RT, Alberts DS, Hersh EM, Salmon SE, Remers WA.

Abstract: A set of 20 2-cyanoaziridine-1-carboxamides was synthesized from 2-cyanoaziridine and appropriate isocyanates. These compounds were active against a variety of solid and hematological tumor cells in culture, including strains resistant to doxorubicin and mitoxantrone. Their potencies in these assays correlated with the lipophilicity of substituents. The N-phenyl derivative was more potent and equally effective to imexon, a cyclized 2-cyanoaziridine-1-carboxamide of clinical interest, against cloned fresh human tumors.

CiteXplore: 9986721

DOI: 10.1021/jm980600x